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ECR 2019 / C-1393
Diagnostic accuracy of ultrasound in differentiating retinoblastoma from persistent hyperplastic primary vitreous (PHPV) in pediatric leukocoria patients with MRI as gold standard
Congress: ECR 2019
Poster No.: C-1393
Type: Scientific Exhibit
Keywords: Congenital, Cancer, Diagnostic procedure, Ultrasound-Colour Doppler, Ultrasound, MR, Paediatric, Oncology, Eyes
Authors: K. F. Farooq1, S. B. Owais2, N. J. Saghir2; 1Islamabad /PK, 2Islamabad/PK

Methods and materials

Patient Population:

This study was conducted at Radiology Department of Foundation University Medical College / Fauji Foundation Hospital, Rawalpindi, Pakistan from January 2016 to September 2018. A total of 56 suspected retinoblastoma patients, 31 males and 25 females, within the age bracket of one month to ten years (mean age 3.11), presenting with leukocoria referred to the hospital by paediatric ophthalmologists were randomly selected. Previously diagnosed patients of retinoblastoma coming for follow up scans were not included. 


Data Acquisition: 

MRI was done on 1.5 tesla Toshiba Vintage Titan machine. T1, T2, FLAIR, T1 FATSAT, post contrast T1 and post contrast T1 FATSAT sequences were done. Images were taken in axial, sagittal and coronal planes. Ultrasound was performed on Toshiba Aplio 500 machineusing high frequency probe of 14 megahertz. To avoid observer bias, ultrasounds and MRI scans were reported by different radiologists. Patients were given general anaesthesia prior to MRI as per guidelines13.
The basis of diagnosis for retinoblastoma on ultrasound was orbital mass with or without calcification and PHPV was diagnosed by the presence of retrolental membrane. 


Data Analysis: 

The data was recorded and analysed using SPSS version 21.0. 

2 X 2 tables were constructed for the ultrasound and MRI findings for characteristic features of each disease i.e. retrolental membrane for PHPV, orbital mass with or without calcification for retinoblastoma. The True Positives (TP), False Positives (FP), True Negatives (TN), False Negatives (FN), sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and diagnostic accuracy were calculated for the ultrasound diagnosis of PHPV and retinoblastoma compared to MRI diagnosis, which was kept as the gold standard.  

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