|ECR 2018 / C-1486|
|Irreversible electroporation (IRE): our experience in percutaneous treatment of intraabdominal tumoral lesions.|
Minimally invasive percutaneous tumor ablation is an established treatment option for focal solid tumors in the liver, kidney, bone and lung, with ever-expanding indication for focal tumors in additional locations.
Irreversibe electroporation (IRE) is a non thermal technique of tissue ablation that allows the destruction of tumor cells using a series of short high-voltage electric pulses that induce cellular apoptosis through the formacion of nanopores in the cell membrane.
Efficacy of current thermal ablation techniques, such as radiofrecuency and microwave, decrease for large tumors (3-5cm) due to limitations in achieving uniform heating at tumor periphery and the counteracting heat-reducing effect of perfusion-mediated tissue cooling, which limits thermal-based coagulation.
Irreversible electroporation is being studied as an alternative ablative technology that can potencially adress several of these limitacion.
Because the main therapeutic principle of IRE is not thermal, the heat-sink effect of flow is no longer a limitacion.
All of these specific properties make IRE an attractive alternative treatment in solid tumors lesions adjacent to critical vascular structure when the other ablative techniques are contraindicated.
Thematically related posters
ECR 2018 / C-1748
Complications Related To Percutaneous Ablation Of Liver Tumors. Know Them To Avoid Them
ECR 2018 / C-3025
Renal tumors treated with ablative techniques: most frequent complications and how to avoid them