ECR 2014 / C-2302
Correlation between Perfusion Micro-Bubble Ultrasound and Perfusion Contrast Enhanced MRI for Carotid Plaque Neovascularization
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Congress: ECR 2014
Poster No.: C-2302
Type: Scientific Exhibit
Keywords: Tissue characterisation, Image registration, Segmentation, Contrast agent-intravenous, Ultrasound, MR, Vascular, Neuroradiology brain, Contrast agents
Authors: W. Abutaleb1, M. J. Graves2, J. H. Gillard2; 1Riyadh/SA; Cambridge/UK, 2Cambridge/UK

Aims and objectives

  Atherosclerotic plaque present within the carotid artery is a major risk factor for stroke (Fig.1) (Hermus, 2010). 


Fig. 1: Stroke and carotid atherosclerosis: strong correlation
References: Wafa Abutaleb, Department of Radiology, University of Cambridge - Cambridge/UK


 To assess the risk of stroke from carotid atherosclerotic disease, the current standard is to measure the severity of luminal stenosis. However, due to the uncertainty in patient management for high-grade asymptomatic stensosis and the failure of stenosis to characterize risk from lesions that do not compromise the lumen, better strategies for risk assessment are needed (Dong, 2009). 


  Few morphological features have been proved to be associated with plaque vulnerability.  In multiple ways, neovascularisation is considered a forerunner of plaque vulnerability  (Abutaleb, 2013).


Fig. 2: Effect of Neovascularisation on the plaque morphology
References: Wafa Abutaleb, Department of Radiology, University of Cambridge - Cambridge/UK



  Perfusion contrast enhanced imaging in both magnetic resonance imaging (DCE-MR) and Ultrasound imaging (DCE-US) shows high potential for accurate characterization of plaque morphology and evaluation of plaque function such as neovascularisation in separate studies (Dong, 2009) (Clevert, 2011). Both methods come with the standard benefits of being non-invasive and avoiding the use of ionizing radiation, which is particularly important for serial imaging studies.


  Correlation between these two different modalities should be carried out in order to qualify the reliability of their outcomes. Furthermore it will indicate the practicality of suggesting either of them as a future tool to undertake plaque characterisation considering various other factors. It will be beneficial to know that both modalities will take us to similar diagnosis (Fig.3).


Fig. 3: Are both DCE-US and DCE-MR leading to similar conclusions in order to detect same risk factors, particularly Neovascularization?
References: Wafa Abutaleb
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