ECR 2013 / C-2592
Characterisation of Neovascularization in Carotid plaque
Congress: ECR 2013
Poster No.: C-2592
Type: Educational Exhibit
Keywords: Haemorrhage, Blood, Biological effects, Imaging sequences, Contrast agent-intravenous, Ultrasound, MR, Vascular, Contrast agents, Arteries / Aorta
Authors: W. Abutaleb, M. J. Graves, J. H. Gillard; Cambridge/UK


  • Level of plaque stenosis is not the sole indicator of vulnerability of the plaques. In fact more than 70% of plaque raptures occor on luminal stenosis of less than 50%.
  • the main risk factors which indicate carotid plaque vulnerability are the degree of stenosis, plaque size and morphology, inflammation, neovascularisation, and downstream effects of atherosclerosis.
  • As carotid plaques are a major cause of ischemic stroke, it would be beneficial to identify patients at high risk of ischemic stroke attributable to carotid artery disease. These patients may then benefit from a timely preventive therapy. The same test may be used for non-invasive monitoring of the preventive treatment and thus potentially contribute to reversing the course of the disease process
  • Two non-invasive modalities have been able to detect neovessels in research level, using dedicated techniques: Dynamic Contrast Ultraound (DCUS) and Dynamic Contrast MRI (DCMR). 
  • According to the preliminary results of my project, DCUS have been more patients' recruiting friendly than DCMR
  • Further studies are recommended, to standardize and evaluate these detecting tools for prospective clinical application.
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