|ECR 2013 / C-2592|
|Characterisation of Neovascularization in Carotid plaque|
- Level of plaque stenosis is not the sole indicator of vulnerability of the plaques. In fact more than 70% of plaque raptures occor on luminal stenosis of less than 50%.
- the main risk factors which indicate carotid plaque vulnerability are the degree of stenosis, plaque size and morphology, inflammation, neovascularisation, and downstream effects of atherosclerosis.
- As carotid plaques are a major cause of ischemic stroke, it would be beneficial to identify patients at high risk of ischemic stroke attributable to carotid artery disease. These patients may then benefit from a timely preventive therapy. The same test may be used for non-invasive monitoring of the preventive treatment and thus potentially contribute to reversing the course of the disease process
- Two non-invasive modalities have been able to detect neovessels in research level, using dedicated techniques: Dynamic Contrast Ultraound (DCUS) and Dynamic Contrast MRI (DCMR).
- According to the preliminary results of my project, DCUS have been more patients' recruiting friendly than DCMR
- Further studies are recommended, to standardize and evaluate these detecting tools for prospective clinical application.
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The stenosis of transplant renal artery diagnosed with contrast-enhanced ultrasound (CE-US) - preliminary report
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