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ECR 2011 / C-1595
Usefulness of MRI for evaluation of neoadjuvant chemotherapy effectiveness and preoperative staging of cervical cancer
Congress: ECR 2011
Poster No.: C-1595
Type: Scientific Paper
Keywords: Oncology, Genital / Reproductive system female, Pelvis, MR, Chemoembolisation, Staging, Surgery, Neoplasia, Pathology
Authors: S. Kharuzhyk, I. A. Kosenko, O. P. Matylevich, T. M. Litvinova, I. S. Dulinec; Minsk Region/BY
DOI:10.1594/ecr2011/C-1595

Methods and Materials

40 consecutive patients aged 25-63 y. o. with clinical stage IIB-IIIB uterine cervical cancer were included in this study approved by institutional board. Informed consent was obtained in all cases.

 

Treatment consisted of one courses of systemic chemotherapy and one course of bilateral UACE with gemcitabine plus lipiodol followed by hysterectomy with pelvic lymphadenectomy.

 

Pelvic MRI was performed before start of treatment and repeated before surgery. Maximal tumor diameter was measured and tumor response evaluated using RECIST criteria [1]. Criterion for partial response was decrease of tumor by more than 30%. If tumor decreased by less than 30% or increased by no more than 20% stabilization was reported.

 

International Federation of Obstetrics and Gynecology (FIGO) classification was used for preoperative MRI staging [2] (Fig. 1). Complete replacement of hypointense cervical stroma ring with tumor nodular protrusion or low-intensity bunds extending to parametrium were considered parametrial invasion signs [3-6] (Fig. 2). Pelvic lymph nodes measured 1 cm or more in short axis were considered enlarged [7]. Preopearative MRI findings were correlated with surgical pathologic examination.

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