Recognize pathophysiology, clinical manifestations and endocrine tumors associated with multiple endocrine neoplasia syndrome. Describe the multimodality imaging features of the endocrine tumors constituting MEN syndrome. Understand the role of follow up imaging and screening in patients with known or suspected gene mutations.
Multiple endocrine neoplasia (MEN) syndrome comprises a spectrum of hormone secreting tumors, usually of autosomal dominant transmission within families [1-4]. The two primary subtypes, MEN 1 and MEN 2, are associated with characteristic benign and malignant endocrine tumors. Imaging plays a vital role in the multidisciplinary treatment approach to these complex tumors. Therefore, it is critical for the radiologist to understand the range of anatomic and functional imaging findings for each...
Imaging findings OR Procedure details
MEN 1 In 1953, Paul Wermer first described a familial syndrome of primary hyperparathyroidism (PHPT), pituitary adenoma and pancreatic neurodendocrine tumor (pNET) which was termed Wermer Syndrome [4-7]. This combination of hormone secreting tumors was later distinguished as multiple endocrine neoplasia type 1, which carries autosomal dominant penetrance with a gene locus on chromosome 11. PRIMARY HYPERPARATHYROIDISM (PHPT) Biochemical Markers- The hallmark of hyperparathyroidism is elevation...
Thorough knowledge of the spectrum of tumors associated with MEN gene mutations aides in the diagnostic workup, post treatment monitoring and screening in patients with MEN related gene mutations.
Correspondence: Arafat Ali DO Email: Alia4@ucmail.uc.edu Twitter: @ArafatAliDO
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