Aims and objectives
The term demyelination denotes loss of myelin with relative preservation of axons.
This results from diseases that either directly damage the myelin sheaths or damage the cells that form them.
Technological advances in recent years have dramatically improved our understanding of these diseases.
Magnetic Resonance Imaging (MRI) has become a critically important tool in the diagnosis and differentiation of different demyelinating disorders.
In this study,
we have focused on the three major...
Methods and materials
Our descriptive cross sectional study was carried out over a period of two years.
40 consecutive patients presenting to our department for imaging with clinico-radiological features of inflammatory demyelinating diseases were recruited into the study.
Common demyelinating diseases were included in the study,
namely multiple sclerosis (Figure 1),
neuromyelitis optica (Figure 2),
acute disseminated encephalomyelitis (Figure 3) and the variants of multiple sclerosis (Figure 4) including...
A total of 40 subjects were analyzed with a total of 241 lesions on imaging being analyzed overall.
The age and sex distribution of the subjects were analyzed.
Majority of the patients in our study were in the age group of 21 to 40 years (45%).
Majority of the patients were female (23),
accounting for 57.5% of the subjects (Figure 9).
Among the total 40 subjects involved in the study,
24 were cases of MS,
14 were cases of ADEM,
and 2 were cases of NMO.
The age distribution of the individual...
DWI hyperintensity is highly sensitive in detecting active contrast enhancing lesions (100% in our study).
However the specificity is lower because of some false positives.
But it can be used as a sensitive screening test with a high negative predictive value for identification of active lesions in cases where administration of contrast is not possible or poses significant risk to the patient,
as it can effectively obviate the need for contrast administration in such cases.
Manohar Kumar Department of Radiodiagnosis VMMC and Safdarjung Hospital New Delhi Rupie Jamwal Department of Radiodiagnosis VMMC and Safdarjung Hospital New Delhi Venkatram Krishnan Department of Radiodiagnosis VMMC and Safdarjung Hospital New Delhi
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