Aims and objectives
Ageing of the global population has become a public health concern,
considering the impact of age-related diseases in terms of healthcare and social costs .
One of the health problems that is emerging is frailty,
a clinical syndrome in which three or more of the following criteria are present: unintentional weight loss (10 lbs in past year),
weakness (grip strength),
slow walking speed,
and low physical activity .
Ageing is a biological process associated with...
Methods and materials
The “New dietary strategies addressing the specific needs of elderly population for a healthy ageing in Europe” (NU-AGE,
http://www.nu-age.eu/) is a large consortium with 30 partners,
from 16 EU countries,
aiming at studying the effect of an elderly-tailored Mediterranean diet by enrolling healthy volunteers of 65 years of age and over in a one year randomized,
controlled trial with two parallel groups (i.e.,
dietary intervention and control) (clinicaltrial.gov:...
Beta-diversity of the microbial communities is represented by Principal Coordinate analysis (PCoA) of the unweighted Unifrac distances.
Three distinct groups of individuals with different microbiota composition were identified ( Fig.
1 ) (Permanova p-value = 0.0001): group A (n=147),
group B (n=20) and group C (n=34).
No differences between non-frail/pre-frail or male/female subjects were observed.
A significantly different relative abundance of the Families Porphyromonadaceae ,...
The present study is an attempt to identify a model of body composition and gut microbiota that could be useful to define better individual at higher risk for frailty syndrome and other age-related diseases.
In our cohort,
3 distinct groups were identified based on gut microbiota composition,
independently of frailty status or sex.
Among these groups,
a significant association was found between group B,
the group showing significantly lower levels of VAT,
and a higher relative abundance...
Piano Mortari A,
Trends in age-related disease burden and healthcare utilization.
2018 doi: 10.1111/acel.12861 2.
McBurnie MA; Cardiovascular Health Study Collaborative Research Group.
Frailty in older adults: evidence for a phenotype.
J Gerontol A Biol Sci Med Sci.
2001 Mar;56(3):M146-56. 3.