Aims and objectives
Toinvestigate the influence of region-of-interest (ROI)placement and different ADC metrics on diagnostic accuracy of diffusion-weighted imaging (DWI) and to assess inter-reader and intra-reader agreement of ADC measurements with DWI in non-mass enhancing (NME) breast tumors with dynamic contrast-enhanced magnetic resonance imaging of the breast
Methods and materials
In this IRB-approved single-institution study and retrospective data analysis 95 patients,
who underwent multiparametric MRI with DCE and DWI and were diagnosed with a suspicious NME breast lesion (BI-RADS 4/5) were included in this study. Two readers independently assessed DWI and DCE in two separate randomized readings with a wash-out period of at least 3 weeks. For DWI readers recorded ADC mean values using: a) Whole tumor (Wtu) ROI,
b) Darkest part (Dptu) tumor 10 mm ROI and c) point...
66 patients (mean ages 51.8 ±10.8 yo,
range 26-76 yo) were included for analysis with a mean size lesion of 40±25 mm,
range 5 mm-98 mm): 39 (59%) malignant and 27 (42%) benign (see Fig.
3). 29 patients excluded; 5 insufficient quality DWI images (24 NME lesions not discernable on DWI alone (12 benign/12 malignant). The best diagnostic performance for DWI for both readers and readings were achieved with Dptu mean with AUC range 0.512 and 0.709 (Fig 4). CCC varied among the different ADC...
Diagnostic accuracy of DWI with ADC mapping is limited in breast lesions presenting as Non- mass enhancement (NME). Best results are achieved using 2D ROI measurements approach and ADC mean
Daly Betzabeth Avendaño Avalos e-mail: firstname.lastname@example.org Twitter account: @dlilahh
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