Aims and objectives
Dynamic PET perfusion imaging (DPPI),
despite its long history,
has become a forgotten technique as clinical perfusion imaging moved to dynamic contrast enhanced MRI and CT.
We intend to redevelop DPPI using next-generation digital PET technology and focus in this Phase I study on thoracic applications.
Next generation digital PET facilitates the clinical use of dynamic acquisition as short whole-body tables times enable more patients to be imaged per hour than typically injection suites are...
Methods and materials
Dynamic FDG PET/CT was performed prior to radiation therapy of advanced thoracic tumors (lung and esophageal) in 24 patients using a next-generation digital photon counting system (Vereos Philips,
dPET). DPPI was performed at the time of bolus injection of ~185 MBq FDG over a volume of interest for 15 min. PET listmode data were reconstructed using a range of 1 sec/fr to 60 sec/fr. Blinded review by two experienced PET readers and descriptive statistics were calculated for data analysis.
Dynamic PET Perfusion Imaging can be readily obtain using current and next-gen digital PET systems.
The image quality was consistenly diagnostic,
however required optimzed reconstruction adjusting for the count sparsity of very short frame times. Fig.2 presents a coronal view of a DPPI at 1min/frame of patient with an esophageal tumor,
Fig.3 using 15 s/ frame both over the first 15 min.
4 at 9 s/frame over 4 minutes and Fig.
5 at 1 s/frame over 1 min. Fig.
6 Present the baseline and...
Dynamic PET Perfusion Imaging (DPPI) was achievable using frame rates of 10 sec with acceptable quality for quantitative and visual assessment even at the low FDG dose of 185 MBq. A short table time of 5 min appears to be sufficient for DPPI acquisition and thus appears to be a clinically viable perfusion imaging methodology that can now be validated in larger trials.
This research and development was performed by a multi-disciplianry team at the Wright Center of Innvation in Biomedical Imaging (WCIBMI) at the Ohio State University Wexner Medical Center and James Comprehensive Cancer Center.
Knopp is Professor of Radiology,
Novartis Chair of Imaging Research and the PI/Director of the WCIBMI.
395 W 12th Ave.,
Knopp MV; Performance evaluation of the next generation solid-state digital photon counting PET/CT system; EJNMMI Res.
2018 Nov 6;8(1):97.
doi: 10.1186/s13550-018-0448-7. Wright CL,
Knopp MV; Advanced Functional Tumor Imaging and Precision Nuclear Medicine Enabled by Digital PET Technologies; Contrast Media Mol Imaging.
2017 May 16;2017:5260305.
eCollection 2017. Wright CL,
Knopp MV; Advancing Precision...