1. Describe the embryological origin of germ cell tumours in various locations. 2.Describe the imaging features for the spectrum of germ cell tumours. 3.Discuss the management of germ cell tumours.
Germ cell tumours most commonly occur in the gonads and are relatively rare in other sites. Extragonadal sites tend to occur in the midline and include the pineal gland,
mediastinum and retroperitoneum. Gonadal and extragonadal germ cell tumours are thought to originate from primordial germ cells.
There are varying pathological subtypes of germ cell tumours with a high prevalence of mixed tumours.
This results in varying radiological features,
which can make interpretation...
Findings and procedure details
Classification of germ cell tumours Germ cell tumours (GCTs)affect both gonadal and extragonadal tissue (figure 1). Histologically they are divided into: 1.Seminomas ( germinoma in pineal gland,
dysgerminoma in ovary) 2.
Nonseminomatous malignant GCTs- embryonal carcinoma,
yolk sac carcinoma,
choriocarcinoma 3.Teratomas Embryology of germ cell tumours. Germ cell tumours (GCTs)are thought to originate from primordial germ cells.
These cells migrate to the primitive gonadal glands in the...
Understanding the radiological findings of the spectrum of germ cell tumours is important to ensure correct diagnosis and management especially as they are potentially curable with aggressive multi modality treatment.
1) Ueno et al,
Spectrum of germ cell tumours: from head to toe.
Radiographics volume 24 no.2.
2004. 2) Scully RE,
Germ cell tumors.
Atlas of tumor pathology: tumors of the ovary,
and broad ligament,
DC: Armed Forces Institute of Pathology,
1998; 239-306. 3) Roasdo-de-Christenson ML,
Meiastinal germ cell tumours:radiologic and pathologic correlatoion.