To assess the role of imaging in making the diagnosis of MO and in MO-related complications,
with emphasis on the balance between radiological protection and diagnostic yield in this frequently young patient population. To learn about the complications that may occur in patients with multiple osteochondromas (MO) and possible treatment options. To emphasize the potential role of total body MR imaging for screening purposes in patients with MO.
Multiple osteochondromas (MO),
previously known as hereditary multiple exostoses,
is an autosomal dominant disorder,
characterized by the presence of at least three either sessile or pedunculated osteochondromas (OC) Fig. 1 Fig. 2 .
In approximately 90% of all cases exostosin-1 (EXT1,
on chromosome 8q24) or exostosin-2 (EXT2,
11p11-13) gene mutations are found. The estimated worldwide prevalence of MO is 1 per 50000; figures might be higher,
as individuals with mild expression without...
Findings and procedure details
Imaging and indications in MO patients Plain radiographs : focus on making the diagnosis (with a positive family history) and screening regarding locations of OC and most important upper and lower limb deformities.
Postoperative monitoring of selected procedures,
ulnar lengthening Fig. 21 Fig. 22 Fig. 23 and hemiepiphysiodesis Fig. 24 Fig. 25 Computed tomography : to be considered for assessment of difficult areas,
and pelvis Fig. 26 .
3D reconstructions add to...
The role of imaging in patients with multiple osteochondromas is pivotal,
directed to the assessment of diagnosis,
location and (preoperative) extension of OC and mapping the various causes of MO-related complications. Given the high amount of imaging examinations frequently performed in this young population,
radiation exposure should always be weighed against the benefits of non-ionizing MRI for different indications,
because of the optimal soft tissue resolution of MRI,
Contributors to this exhibit: Henk-Jan van der Woude,
MSK radiologist Dpt of Radiology Onze Lieve Vrouwe Gasthuis Oosterpark 9 1091 AC Amsterdam,
The Netherlands E: email@example.com Jeroen Markenstein,
resident in radiology Dpt of Radiology Onze Lieve Vrouwe Gasthuis Oosterpark 9 1091 AC Amsterdam,
The Netherlands E: firstname.lastname@example.org John Ham,
orthopedic surgeon Dpt of Orthopedic Surgery Onze Lieve Vrouwe Gasthuis Oosterpark 9 1091 AC Amsterdam,
Secondary chondrosarcoma in osteochondroma: report of 107 cases.
Clin Orthop 2003; 411: 193-206 Bernard SA,
Kransdorf MJ. Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging.
Radiology 2010; 255: 857-865 Darilek S,
Hereditary multiple exostosis and pain.
J Pediatr Orthop 2005; 25: 369-376 Gavanier M,