Aims and objectives
The critical biological characteristic of a Glioblastoma (GBM) is an inevitable progression after standard therapy with survival less than one year (mean 6,9 months) from the time of diagnosis. Tumor recurrence develops in almost all patients despite the aggressive standard first line treatment with radiotherapy and concomitant or adjuvant temozolomide (RT + TMZ). Thus,
prediction of poor treatment response (early relapse) to the standard first line treatment of GBM is of high clinical...
Methods and materials
Study population: 27 patients with recurrent GBM were selected from the local database for the period from 2012 to 2018 and enrolled in the retrospective study. The recurrence was proven either with surgical biopsy or MRI surveillance. Prior to the relapse event all patients undergone gross tumor resection and received Intensity Modulated radiation therapy (IMRT) combined with concurrent or adjuvant temozolomide as a primary treatment of high-grade Glioblastoma. Data acquisition: MR...
Total of 27 patients with GBM progression on the structural MRI were retrospectively included into this study.The basic characteristics of the study sample are summarized in Table 1. The study sample was divided into two subgroups of early (less then 4 months) and late (over 4 months) recurrence.
Thirteen patients presented with early relapse within 4 months after the end of IMRT; fourteen patients developed late recurrence (5 – 72 months). The independent-samples Mann-Whitney U test (Table...
Baseline Glioblastoma MRS parameters have predictive potential in early vs late recurrence patient stratification. The predictive capacity of acquired logistic regression model provides the possibility to develop a scoring system by weighting dummy-coded variables and assigning scores to each MRSI and DWI parameter.
Therefore we plan on inter-institutional expansion of the study cohort to apply the scoring system of acquired cut-offs and validate the accuracy in a prospective...
Debora Bertholdo MD,
Arvemas Watcharakorn MD,
Mauricio Castillo MD,Brain Proton Magnetic Resonance spectroscopy introdaction and overview.
Neuroimag Clin N Am 23 (2013) 359–380. https://doi.org/10.1016/j.nic.2012.10.002 Barajas RF,
Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging....