Aims and objectives
The Human Papilloma Virus (HPV) is currently responsible for an increasing number of head and neck cancers,
regardless of exposure to smoking and drinking [1,2].
The oropharynx is the most affected site because the virus replicates in the lymphoepithelial tissue of the palatine and lingual tonsil . HPV-positive(HPV+) squamous cell carcinomas of the oropharynx (OPSCC) have a better prognosis than their HPV-negative (HPV-) counterparts and respond better to chemo and radiotherapy .
Methods and materials
We retrospectively evaluated patients diagnosed with OPSCC(palatine tonsils and tongue base). 81 patients were recruited regardless of tumour staging; of these,
12 were excluded because they had not undergone contrast-enhanced staging CT in our hospital and 7 were excluded due to important artefacts from metal implants or dental amalgam ( Fig. 3 ). 62 patients were finally included,
44 men and 18 women,
the age ranged from 42 to 81 years.
HPV status was established by evaluating...
33 patients were HPV-positive and 29 HPV-negative. Eight patients had no identifiable primary lesion: 5 were HPV+ and 3 HPV- and were excluded from the assessment of the primary lesion. Nine patients had no lymph node metastases: 4 were HPV+ and 5 were HPV- and were excluded from the morphological evaluation of lymphadenopathy. Exophytic growth pattern of primary tumour was found in 17/28 (61%)HPV+OPSCC and in 9/26 (35%) inHPV-OPSCC without statistically correlation,
although it was more...
Our case series shows a statistically significant correlation between: - the cystic changes of the lymphadenopathy and the presence of HPV+ status - thedeep muscle invasion of the primary lesion and the HPV status according to the literature [6-8] (Fig. 13). The invasion of deep muscles and the more typically infiltrative aspect of HPV- OPSCC is correlated to a greater aggressiveness of these tumours given by numerous gene mutations induced by exposure to smoke and alcohol,
as opposed to HPV+...
Giovanni Battista Verrone Department of Radiology,
Careggi University Hospital,
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doi: 10.1016/S1470-2045(10)70017-6 Castellsagué X,
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