Aims and objectives
Glioblastoma is the most frequent and agressive brain neoplasm in adult population.
The initial diagnosis using multiparametric MRI is not so hard,
but the differentiaton of recurrent tumor,
postoperative changes and radiation necrosis could be challenging.
with modern perfusion and diffusion techniques this conditions could be separated on MRI on easy way.
with rapid developing of different puls sequences and abscence of standartised assessment algorythms...
Methods and materials
36 patients with glioblastomas after partial resection were examined on 1.5T MRI unit with 24-channel RF head coil before irradiation. Scanning protocol included DSC-perfusion with semi-automatic perfusion maps postprocessing,
3D ASL with automatic CBF map generation and Diffusion-weighted Imaging using b-values of 0 and 100 and automatic generation of ADC map.
DSC-perfusion was scanned with whole-brain coverage,
5 mm slice thickness using a multiple 2-second imaging series.
No significant correlation between normalized (n)CBV (DSC) and nADC was found (p=0.05).
both nCBF (DSC) and nCBF (ASL) showed similar linear correlation with nCBV (DSC): 0.678 and 0.679 respectively.
Kendall coefficient was higher in nCBF (DSC) than in nCBF (ASL): 0.704 and 0.527 respectively.
Mean nCBV was 11.43.
CBV is a well-known imaging biomarker useful for gliomas grading due to strong correlation with tumor angiogenesis.
Glioblastomas always show high CBV values due to high vascularity.
Interest of this work was in comparing other imaging techniques quantative parameters such as diffusivity (ADC) and CBF made by standard contrast-enchanced DSC technique and non-contrast enchanced ASL method.
Achieved data shows nCBF as a promising imaging biomarker in glioblastomas recurrence diagnosis.
Longitudinal DSC-MRI for distinguishing tumor recurrence from pseudoprogression in patients with a high-grade glioma.Am J Clin Oncol.2014 2.
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Prognostic value of perfusion-weighted imaging in brain glioma: a prospective study.Acta Neuro-chir (Wien)2006;148(3):277–285 3.