Aims and objectives
Lung cancer is the leading cause of cancer related death .
Presence of emphysema or/and chronic pulmonary obstructive disease (COPD) is known risk factor for lung cancer [2,
Never-smokers are also at greater risk for lung cancer if they have emphysema .
there is a correlation between severity of airways obstruction and risk of developing lung cancer [2,
Similar correlation is reported in some studies concerning emphysema .
The aim of this retrospective study...
Methods and materials
Between February 2009 and April 2011,
8649 asymptomatic healthy volunteers in the age of 50-75,
with at least 20 pack-years smoking history underwent chest Low-Dose Computed Tomography (LDCT) screening in the Pilot Pomeranian Lung Cancer Screening Program.
Both former and current smokers were included in the program.
For patients with family history of lung cancer,
minimum history of smoking was ten pack-years. A questionnaire included age and gender and complete smoking history was...
283 participants with nodules diameter >10 mm or with suspicious tumor morphology were enrolled to diagnostic work-up.
In 175 individuals spirometry was performed.
14 patients with performed spirometry were excluded because their original LDCT could not be acquired for retrospective evaluation. Finally,
a total number of 161 patients were included in the analysis.
63 participants were lung cancer positive (LCP) and 98 lung cancer negative (LCN).
Both groups were similar according to gender...
Our retrospective study investigated the association between lung cancer occurrence and COPD or emphysema in smokers.
We noted the significant correlation between smoking history and size of tumor and risk of lung cancer.
We also found,
that there is no statistically significant association between the incidence of lung cancer and COPD,
regardless of the severity of airflow obstruction.
Additionally no statistically significant correlation was found between the incidence of lung cancer and...
Screening for lung cancer: time for large-scale screening by chest computed tomography.
Eur Respir J.
2014 Jul; 44(1):217-38. Mannino DM,
Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up.
Arch Intern Med 2003;163:1475–1480. Brenner DR,
Previous lung diseases and lung cancer risk: a systematic review...