Aims and objectives
Bi-parametric prostate MR (bp-MR) is a valuable tool for detection and characterization of prostate cancer (PCa).
It has been proven that its diagnostic performance is not inferior to that of multi-parametric MR (mp-MR) while having lower costs and requiring less time to perform [1,
2]. Prostate specific antigen density (PSA-D) is a parameter derived from a ratio of PSA blood levels and prostate volume.
Its increase has been correlated with the presence of clinically significant PCa (csPCa)...
Methods and materials
We retrospectively analyzed 334 consecutive patients who underwent prostate MR on a 3T scanner.
Only patients (n=114) who underwent a TRUS-biopsy within 30 days of MR and had no previous prostate biopsies were considered. All MR scans were acquired on a 3T scanner (Magnetom Trio,
Siemens Medical Solutions,
Germany) using the standard surface phased-array coil and integrated spine phased-array coil (Body Matrix,
Siemens Medical Solutions). Acquisition protocol included for all...
The final population (n=114),
had a mean age of 65.75 years (SD ± 7.93),
a mean prostate volume,
calculated on MR images,
of 61.37 ml (SD ± 27.73 ml),
a mean PSA serum level of 7.76 ng/ml (SD ± 6.46 ng/ml) and a mean PSA-D value of 0.14 (SD ± 0.12).
Among the 114 patients,
61 (54%) had a histopathologically proven PCa. Both bp-MR and PSA-D were significant predictors of csPCA; however,
sensitivity was higher for bp-MR than PSD-D (93% vs 77%) with comparable specificity (74% and 73%,...
Our results confirm that bp-MR is a powerful tool for detection of csPCa in patients with a clinical suspicion.
While PSA-D was useful in identifying patients with csPCa,
contrary to findings in the recent literature,
it does not appear to significantly improve diagnostic performance of bp-MR. These findings reinforce the notion that bp-MR should have a pivotal role in the future management of patients with PCa,
especially before any biopsy is performed,
as it may help avoid unnecessary...
Biparametric 3T Magnetic Resonance Imaging for prostatic cancer detection in a biopsy-naïve patient population: a further improvement of PI-RADS v2? Eur J Radiol.
2016;85(12):2269-2274. Kuhl CK,
Abbreviated Biparametric Prostate MR Imaging in Men with Elevated Prostate-specific Antigen.
2017;20:170129. Kundu SD,