Aims and objectives
Breast cancer is the most common cancer in women worldwide.
Neoadjuvant chemotherapy (NAC) has become increasingly used in the management of breast cancer.
Initially introduced to facilitate resection of inoperable cancers,
it is now also employed in early operable (stage T2 and T3) tumours,
permitting less radical surgery [1-3].
Standard NAC regimens involve six to eight cycles (fortnightly) of combination chemotherapy regimens,
commonly adriamycin and cyclophosphamide followed by docetaxel...
Methods and materials
Material and Methods Ethical approval was granted by the Clinical Research Ethics Committee,
Galway University Hospital. Patient Selection 11 Patients who underwent NAC in Galway University Hospital in 2012 were invited to participate in this prospective cohort study,
oncethey were over 18 years of age and provided written informed consent. Breast MRI Breast MRI was performed (Magnetom Espree 1.5 Tesla,
Siemens Medical Systems,
Germany) pre and post-NAC.The patient lay in the prone...
Patient details are presented in Table 1 (Figure 2).The mean patient age was 50.3(±8.3) years.There was no correlation between MRI response and pathological response in this patient cohort (p=0.555).
MRI responses varied.
MRI complete response was achieved in 2 patients (partial n=7,
There was no significant difference between MRI response groups in circulating miR-195 expression at diagnosis (p=0.478,
see Figure 3),
peri-NAC (p=0.745) and post-NAC (p=0.689,
MRI is performed pre and post-NAC to help evaluate response to NAC preoperatively. MiR-195 is not a useful substitute for MRI for evaluation of response in this cohort.
this preliminary study contributes towards the evolving field of radiogenomics.
The current era of tailored treatment has a need to identify biomarkers to facilitate the correlation of radiological findings with those on a molecular levelwith the aim of enhancing the application of non-invasive imaging modalities in...
McDermott MD PhD Department of Radiology, Galway University Hospital, Saolta University Health CareGroup, Galway,
Ireland email: email@example.com
et al., Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol.,
2006. 24 (12): p.
et al., Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol,
1998. 16 (8): p.
2672-85. van der Hage,
et al., Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research...