Aims and objectives
Introduction: MR imaging in arthritis is increasingly used.
A thickened synovial membrane is considered a marker of active arthritis in both juvenile and adult arthritides[1,2].
Synovial thickness is determined on post-contrast T1W MRI to ensure differentiation of joint fluid from synovial membrane. Timing of acquisition of post-contrast MR images for the assessment of the synovial membrane is important: delayed acquisition can result in contrast washout into synovial fluid  and thus...
Methods and materials
Patients: we included children diagnosed with JIA who were having current or past knee arthritis and subsequently underwent clinical knee MRI.
Written and verbal informed consent for participation in our IRB-approved study was obtained from patients and parents. 1Tesla MRI: our standard JIA protocol ( Table 2 ) was acquired,
with in addition an axial dynamic contrast-enhanced T1-weighted scan (voxel size 1x1x3.5) which was used for measurement of the maximal synovial thickness of the...
Subjects: 53 JIA patients (59%females),
were included and the mean age of the children was 13.5 years. Fig. 3 and Fig. 4 show representative images of two included JIA patients. Table 2 showsadditional patient characteristics. Synovial thickness For graphical representation of results: see Fig. 5 Median synovial thickness of the two readers averaged was: 1.4 mm (IQR 1.1-1.7) for TP 1 (1 min.
post-contrast) 1.5 mm (IQR 1.4-1.9) for TP 2 (5 min.
post-contrast), --->the difference was...
It is well known that timing of post-contrast sequences is of utmost importance for assessment of synovial inflammation.
Our study is the first to add quantitative data to the literature about the relation between synovial thickness and the interval between contrast administration and acquisition of the post-contrast images.
We confirmed our hypotheses that: synovial thickness as measured on post-contrast MRI increases with a prolonged interval between contrast administration and acquisition...
email@example.com Department of Radiology and Nuclear Medicine & Department of Pediatric Immunology,
Hematology and Infectious Diseases Academic Medical Center/Emma's Childrens Hospital University of Amsterdam Amsterdam,
The Netherlands If you have a question,please contact me (firstname.lastname@example.org)or connect on: Research gate LinkedIn
Van den Bossche V,
De Rycke L et al (2006) Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis.
Arthritis Rheum 54:2594-2604. Østergaard M,
Conaghan P et al (2003) OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies.
Core set of MRI acquisitions,
joint pathology definitions,
and the OMERACT RA-MRI scoring system.
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Klarlund M (2001)...