Review the different manifestations of chronic granulomatous disease in children. Describe the pathogenesis of the disease and its relation with the radiological findings. Remark the radiographic patterns of disease. Give key clues for adequate differential diagnosis.
Chronic granulomatous disease (CGD) is a disorder of the immunity that affects the phagocytic cells caused by a defect in the nicotinamide adenine dinucleotide phosphate (NADPH),
which leads patients vulnerable to recurrent Infections by catalase-positive organisms,
persistent inflammation and granuloma formation.
Usually affects boys becauseis caused by a mutation in the cytochrome B gene that is located on the X chromosome. This entity may affect different systems but the patients usually...
Findings and procedure details
The purpose of this review is present the radiological findings in chest imaging of children with chronic granulomatous disease from our hospital. Defects in phagocyte function ofCGD usually manifests in infancy or childhood as recurrent infections by organisms such Staphylococcus aureus , Psedomonas sp, Nocardia sp and fungi ( Aspergillus species and Candida albicans ). 1 Other manifestations includesgranulomatous disease and inflammation. The most common complication of CGD is pneumoniabut...
Chronic granulomatous disease in children leads to recurrent infections,
inflammation and granulomas formation,
The lung is the most frequent site of compromise.
It is important that the radiologist know this disease and its multisystem compromise in order to communicate relevant information to the medical group.
et al.Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy .
2011; 9: 10. 2.Khanna G,Kao S,Kirby P,Sato Y. Imaging of Chronic Granulomatous Disease in Children.
RadioGraphicsSeptember-October 2005, Volume 25,
Issue 5 .