The purpose of this essay is to: Review structural and functional imaging abnormalities on positron emission tomography / computed tomography (PET/CT); Correlate important findings with the clinical,
anatomy and pathogenesis of non-oncological thoracic diseases; Identify their characteristics in order to familiarize radiologists with these conditions; Emphasize the most important radiologic features on PET/CT.
The role of PET with fluorodeoxyglucose (FDG) technique is well established in the management of patients with lung cancer and its combination with CT has become an essential imaging tool in oncological practice.
FDG is not a cancer-specific agent,
false positive findings in nononcological diseases have been reported. Being a glucose analogue,
FDG has an affinity towards glucose receptors on cell surface and their sites of accumulation in acute infection / inflammation are migratory...
Findings and procedure details
NORMAL VARIANTS AND PHYSIOLOGICAL FDG UPTAKE: MYOCARDIUM ( Fig. 2 ) uptake of FDG in patients ranges from uniform and intense to absentdue to the fact thatthe myocardium uses free fatty acids as its primary substrate,
but in the nonfasting state the antilipolytic effect of insulin reduces the delivery of free fatty acids,
and the heart relies more on glycolytic metabolism (insulin-sensitive glucose transporters).IncreasedFDG uptake has also been reported in lipomatous hypertrophy of the...
Increased metabolic rates can be misinterpreted as malignant lesions.
These pitfalls are commonly encountered and them can be classified into those that yield potential false-positive or false-negative results. Potential false positives include physiologic FDG uptake (myocardium,
breast in lactating females,
muscles and brown fat) and increased FDG activity in benign conditions such as fungal and bacterial infections,
Lucas de Pádua Gomes de Farias - Hospital Alvorada,
Faculdade de Medicina da Univeridade Federal de Alagoas,
Brazil. Igor Gomes Padilha - Faculdade de Medicina da Univeridade Federal de Alagoas,
Brazil. Daniel Cunha Menezes - Faculdade de Medicina da Univeridade Federal de Alagoas,
Brazil. Maria Lúcia Lima Soares - Faculdade de Medicina da Univeridade Federal de Alagoas,
Brazil. Wander Mattos Cardoso -Clínica de...
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