To describe MR findings in patients with advanced breast cancer after neoadjuvant chemotherapy with correlation with pathological changes occurring during treatment . To illustrate a model of report for MR studies after neoadjuvancy ,including the parameters that should be reported,
withcorrelation with pathological findings of surgical specimen reporting.
Currently neoadjuvant treatment is considered a primary indication in breast cancer,
primarily non-operable and inflammatory breast cancer. The main objective of neoadjuvant treatment is tumor reduction which may allow breast-conserving surgery,
or improve surgical cosmetic outcomes. Other benefits are in-vivo confirmation of tumor response with a prognostic implication as presence of pathologic complete response (pCR) is a predictor of patients with improved survival,
Findings and procedure details
Imaging evaluation with MR is the most accurate technique in breast cancer with neoadjuvant treatment,
both for evaluation of tumor and lymph nodes. In the study protocol for breast cancer at our Institution, MR imaging was performed in every patient at the moment of diagnosis (before treatment),
and posttreatment (within one week after neoadjuvant treatment and one week before surgery) . In order to obtain a useful MR report ,
a series of parameters which correlate with pathological...
Imaging evaluation with MR is useful in breast cancer with neoadjuvant treatment,
both for evaluation of tumor and lymph nodes. Imaging features correlate with pathological findings after surgery. Complete response may be detected. In residual tumor analysis the main imaging parameters to correlate with pathology are initial tumor size and morphology,
residual tumor size and pattern of response,
contrast enhancement pattern,
and diffusion weighted MR . In lymph node analysis presence and...
Lorente Ramos 1 ( firstname.lastname@example.org ) J.
Azpeitia Arman 1 M.A.
Lara Álvarez 2 C Oliva Fonte 1 M T Rivera García 3 Unidad Central de Radiodiagnóstico de la CAM: Hospital Universitario Infanta Leonor 1 Oncology Department.
Hospital Universitario Infanta Leonor 2 Pathology Department.
Hospital Universitario Infanta Leonor 3 Madrid SPAIN
A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival.
Breast 2003;12:320-7. Symmans WF,
Hatzis C Rajan R,
Hennessy B, Green M,
Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy.