Aims and objectives
Diffuse gliomas are the most common primary cerebral tumor of adulthood.
In the management of gliomas,
the World Health Organization tumor grade is an important prognostic factor along with clinical and radiologic findings.
Molecular and genetic biomarkers of gliomas,
EGFR and Ki-67 index,
are also emerging prognostic factors predicting the biological behaviour of tumors. Dynamic susceptibility-weighted contrast-enhanced (DSC)imaging remains the most commonly used...
Methods and materials
Patient Selection and Histopathological Analysis From February 2013 to July 2016,
we conducted a retrospective analysis of forty-nine patients with histologically proved diffuse gliomas. Following surgical resection or biopsy,
two experienced neuropathologists provided histological diagnosis by using the 2007 WHO classification.
Histologic specimens were classified into grade II-IV diffuse gliomas based on the presence of astrocytic or oligodendroglial morphology,
Study population A total of forty-nine patients with diffuse gliomas were enrolled in the study.
This retrospective analysis included 28 male and 21 female patients,
with age ranging from 16 to 78 years. Gliomas were classified into forty-one high-grade and 8 low-grade tumors.
in the group fo high-grade gliomas,
24% of the patients were positive for IDH mutation,
32% had methylated MGMT and 12% had ATRX loss.
Mean follow-up was 15 months. Correlation of DSC and DCE Permeability...
The results of our study demonstrate a significant correlation between the perfusion parameters leakage (DSC),
Ktrans and Vp (DCE). Both DSC and DCE perfusion MRI-derived parameters can serve as a noninvasive method for approximating tumor grade. Ve and Ktrans were the best parameters distinguishing high- and low-grade gliomas. Leakage was the only perfusion parameter significantly related to OS and PFS; with prolonged survival for patients with leakage values lower than 1.2.
Leakage was also...
MD PhD Department of Radiology,
Universitary Hospital 12 de Octubre,
1. Nguyen TB,
Comparison of the Diagnostic Accuracy of DSC and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas.
AJNR Am J Neuroradiol 2015;36:2017-22. 2. Boxerman JL,
Paulson ES; et al.
The Role of the Preload and Leakage Correction in Gadolinium-Based Cerebral Blood Volume Estimation Determined by Comparison with MION as a Criterion Standard.
AJNR Am J Neuroradiol 2012;33:1081-87. 3. Skinner JT,