Oxygen deprivation before or around the time of birth often results in hipoxia-ischemia-induced brain damage,
which remains a common cause of neonatal injury,
and affects 1 to 3 per 1000 live births in developed contries with incidence increased up to 26 per 1000 live births in the developing world. The pattern of injury depends on the level of the development of the brain and on the severity and duration of the insult. Neonatal encephalopathy resulting from hypoxic-ischemic injury is...
It is now well established that hypoxic-ischemic brain injury is a syndrome that evolves over days , even weeks ,
and reflects the evolution of a delayed cascade of molecular events triggered by the initial insult. During normal conditions ,
the human brain has a high requirement for oxygen andglucose,
normally used in oxidative phosphorylation to produce adenosine triphosphate (ATP). During a hypoxic-ischemic episode ,
oxidative phosphorylation is rapidly reduced leading to primary energy...
Findings and procedure details
PRETERM HYPOXIC-ISCHEMIC ENCEPHALOPATHY Hypoxic-ischemic injury is more common in preterm neonates than in term neonates.
At least 5% of infants born before 32 weeks gestational age and up to 9% of infants born before 28 weeks develop cerebral palsy. Due to the immadurity of the preterm neonatal brain , imaging findings of hypoxic-ischemic injury in preterm neonates differ from those seen in term neonates . • SEVERE ASPHYXIA Profound hypoxic-ischemic events in preterm neonates manifestates...
Imaging findings in hypoxic-ischemic encephalopathy are highly variable and depend on a number of factors,
including brain maturity,
severity and duration of the insults,
and type and timing of imaging studies. Points to take home ( Fig. 25 , Fig. 26 and Fig. 27 ).
Amaya Hilario MD PhD Radiology Department,
Universitary Hospital 12 de Octubre,
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