To study magnetic resonance imaging (MRI) features of recurrent/progressive meningiomas showing increased uptake of 18F-choline on positron emission tomography (18F-choline-PET).
Meningiomas are non-glial neoplasms originating from the meningocytes or the arachnoid cap cells of the meninges.
They are the most frequent primary brain tumors and represent approximately 20-30% of all primary intracranial neoplasms [1-2] with an annual incidence of about 4-5 per 100.000 individuals .
The incidence increases progressively with age,
change by race (with a black to white ratio of 2:1 ) and sex,
being more common in women (female to male ratio of about 3:1 )....
Findings and procedure details
42 patients (15 men and 27 women,
average age 58 years) having meningiomas that were surgically treated and clinically followed-up with MRI at our institution during the period 2009-2017 were included.
6 patients having increased uptake on 18F-choline on PET (3 men,
average age 60.6 years) and recurrent/progressive meningiomas were identified. Of these 6 patients,
histology demonstrated: 2 meningotheliomatous meningiomas (WHO Grade I) and 4 atypical meningiomas (WHO Grade...
Recurrent/progressive meningiomas (RPM) having increased 18F-choline uptake on PET tend to show a pattern of signal changes/appearance on MRI similar to other malignant primary brain tumors.
This includes high T2,
low ADC values and no decreased SWI,
findings that may reflect the high cellularity/atypia present in RPM.
Since our study is small,
there is further need for larger evidence with F18-choline PET in meningiomas,
and for longitudinal studies.
Perry A LD,
von Diemling A.
In: Louis DN OH,
World Health Organization Classification of Tumours of the Central Nervous System.
ed.Lyon: IARC 2007.
Histological classification and molecular genetics of meningiomas.
doi:10.1016/s1474-4422 (06)70625-1PMID:17110285. 3.
Statistical report: primary brain...