● Functional and clinical validation of imaging biomarkers of airways and lung parenchyma in cystic fibrosis by its correlation with pulmonary function tests. ● Correlation of these biomarkers with a clinical variable (sputum colonization).

Retrospective study of patients diagnosed of cystic fibrosis who have undergone CT before lung transplantation in 2012 or later. Inclusion criteria were: ● Patients older than 18 years old at the time of CT. ● MDCT study closer to transplantation surgery, so in the most advanced degree of cystic fibrosis. ● MDCT acquisition at maximal inspiration. ● Images reconstructed using mediastinum filter, with 1 mm slice thickness and overlap of 50% between slices, allowing an appropriate...

Table 1 summarizes the results of quantitative variables: age, forced expiratory volume in one second (FEV1), total lung volumes (considering both lungs), volumes of emphysema and hyperlucent lung (measured in both lungs) and its percentage relative to total lung volume. ● Correlations between the quantized lung volumes and clinical parameters show that there is no correlation between FEV1 and volume of hyperlucent lung, both quantified by the fixed threshold model or adaptive threshold model...

● The automatic quantification of pulmonary emphysema shows a statistically significant association with the percentage of FEV1. A larger volume of hyperlucent lung correlates with lower FEV1 (negative correlation). ● Quantification by adaptive threshold method gets better correlation with FEV1 than that performed by fixed threshold method. ● A statistically significant association between low FEV1 values and the presence of bacterial colonization in sputum is observed. ● It has been not...

1. Saguintaah M, Cabon Y, R Gauthier, Duboibaudry C, Couderc L, Le Bourgeois M, et al. A simplified, semi-quantitative computed tomography structural lung disease outcome During quiet breathing in infants With Cystic Fibrosis. J Cyst Fibros. 2017 January; 16 (1): 151-7. 2. Rosenow T, K Ramsey, Turkovic L, Murray CP, Mok LC, Hall GL, et al. Air trapping in early cystic fibrosis lung disease CT-does tell the full story? Pediatr Pulmonol. 2017 September; 52 (9): 1150-6. 3. WT Miller, Chatzkel...