Breast cancer is a heterogeneus disease.
Nowadays immunohistochemical patterns are very important to classify the tumors acording to their aggressivity and prognostic factors.
Luminal A tumors can have a very good prognosis,
while triple-negative and pure Her-2 cancers can be very aggressive. Both mammography and tomosynthesis are very sensitive to spiculations,
but not as sensitive to detect masses in dense breasts.
US can detect masses in dense breasts,
but fails to...
Methods and materials
lesion-based study was approved by the IRB. 277 cancers,
were reviewed from October 2011 to September 2016.
Out of them,
30 pure intraductal cancers were excluded. Our final sample consisted on 247 invasive cancers.
All of them were previously studied with mammography,
tomosynthesis ans US. Imaging evaluation Both DM and DBT studies were performed using a Siemens Mammomat Inspiration unit (Siemens Medical Solutions,
Among the 247 cancers reviewed,
there were 208 invasive ductal carcinomas (IDC),
36 invasive lobular cancers (ILC) and 3 malignant phyllodes tumors. The distribution of the density pattern of the breasts was as follows: ACR a: 6 (2.4%) ACR b: 108 (43.7%) ACR c: 103 (41.7%) ACR d: 30 (12.1%) The distribution of the immunohistochemical patterns of the lesions was as follows: Luminal A: 127 (51.4%) Luminal B: 80 (32.4%) Pure Her-2: 9 (3.6) Triple negative: 31 (12.6 %) The mean size of the tumors...
Additional US significantly increased the sensitivity of mammography in all immunohistochemical patterns. For Luminal A cancers: Whatever the combination of mammography plus an additional technique,
the sensitivity is significantly higher than for mammography alone(MXUS (84%) and MXDBT (78%) vs MX (46%); p<0.001 for both comparisons). At comparingMXUS vs MXDBT no significant differences were found (p=0.185).
This means both combinations worked similarly. For Luminal Bcancers: Whatever the...
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