Clinical management of patients affected by breast cancer in pregnancy.
Pregnancy-Associated Breast Cancer (PABC) represents about 3% of malignant breast tumors. During pregnancy,
increased blood levels of estrogens and progesterone lead to important modifications of breast structure,
with augmented volume and density of the gland. This tends to present a diffused nodular structure that may conceal potentially palpable breast lesions.
As a consequence,
most of PABC are diagnosed with delay. Moreover,
these neoplasms tend indeed to be more aggressive: these...
Findings and procedure details
An Ultrasound examination was only performed,
showing sospicious hypoechoic mass in all cases. A needle biopsy was executed to all patients. PATIENT ONSET GESTATION WEEK HYSTOLOGY BIOLOGY METASTASES AT ONSET TREATMENT FOLLOW-UP (2 years) M.D.
32Y Carcinomatous mastitis left breast 27 Ductal invasive carcinoma RE: 90%; RP:5%;Ki67: 74%; Her2: +++ Liver and bones CT Neoadiuvant (cyclophosphamide and Epyrubicin) till delivery at 36° week.
Then CT adjuvant with Pertuzumab,
Diagnosing breast cancer in pregnancy may often be difficult,
given the gestational physiologic modifications of the gland that cause a diagnosis delay of 1-2 months,
often when the disease has already spread. At presentation,
the disease is more frequently a palpable mass,
with thickening retractable skin,
rarely with blood secretions. The first approach for diagnosis is ultrasound,
which shows high sensitivity and specificity,
being the right approach to discriminate between solid and...
Dr.ssa Ilaria Mancarella Spec.in Radiologia
Casa di Cura Santa Maria - Bari email@example.com +39 80 5040290 Dr.
Gianpiero Berardi Spec.in Radiologia
Casa di Cura Santa Maria - Bari firstname.lastname@example.org +39 080 5040290 Dr.
Vito Alberotanza Azienda Ospedaliero-Universitaria Consorziale Policlinico - Bari U.O.C.
Radiodiagnostica Universitaria email@example.com +39805478840
Amant F et al.
Breast Cancer in pregnancy: Recommendations of an international consensus meeting.
Eur J Cancer (2010). Basta P et al.
Cancer treatment in pregnant women.
Contemp Onc 2015; 19 (5): 354-360.
Preliminary monocentric results of biological characteristics of pregnancy associated breast cancer,
Breast 2014; 23(1):19-25. Kakoulidis I,
Pregnancy associated breast...