Aims and objectives
Prostate cancer (PCa) is the second most common cancer and the sixth cause of cancer related death in males worldwide .
The United States’ National Cancer Institute estimated 233,000 new cases and 29,480 deaths from PCa in 2014. Prostate cancer is potentially curable if early diagnosis is achieved,
but is difficult to detect using conventional techniques.
In gray-scale ultrasound (GSU),
PCa is most often depicted as a hypoechoic area but it may also appear echogenic or isoechogenic.
Methods and materials
Between January and December 2013,
we evaluated 72 patients with PSA levels of 2,
5 ng/ml or grater and 10,
0 ng/ml or less who were scheduled for prostate biopsy. All patients underwent GSU and RTSE prior to biopsy by using a transrectal end fire multifrequency probe supplied with strain elastography software,
wich was performed by a single radiologist. Elastograms were obtained by slight prostate compression and decompression along the peripheral zone,
since most cancers originate from this...
Prostate cancer was detected in 19 of 72 patients.
The estimated prevalence value was 26.38% (95% CI 16.53% to 36.97%). The PC detection rate was significantly higher in RTSE-guided suspicious areas compared to the GSU-suspicious areas at 70.83% (51 of 72) vs 41.66% (30 of 72),
(difference between the proportions = 29.17%,z = -4.00,
p <.001). Sensitivity and specificity to detect PCa was 100% (95% CI = 79.90% to 1) and 40.38% (95% CI = 27.30% to 54.80%) for RTSE,
being the Kappa concordance...
despite the increasing knowledge of prostate imaging characteristics,
no available technique can safely stratify cancer lesions from benign prostate tissue. GSU remains the gold standard method to guide prostate biopsies. Due to its low sensitivity for PCa detection,
prostate biopsies are taken systematically ,
rather than targeted,
thus increasing the costs and the risks to the patient. New imaging modalities are needed to increase the accuracy of targeted biopsies.
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