Aims and objectives
To evaluate the feasibility of 3D Cube-IDEAL/Flex sequence in the evaluation of response to neo-adjuvant chemotherapy without contrast media in patients with breast cancer,
in comparison with 2D T2 fast spin echo sequence with fat suppression.
Methods and materials
30 patients with proven breast cancer (BIRADS 6) detected at x-ray mammography (Mx) and ultrasound (US),
candidate for neo-adjuvant chemotherapy (age 18-70 years old),
underwent standard MR examination with contrast media administration,
including Cube-IDEAL/Flex and 2D T2 FSE fat-sat sequences.
Two independent breast MD radiologists evaluated 3D Cube-IDEAL/Flex and the 2D T2 FSE images based on contrast resolution,
lesion contour delineation (if applicable),
No significant differences were found in the lesion size evaluation between the two sequences for both radiologists.
The images quality of Cube-Flex and Cube-Ideal was considered better,
for both radiologists,
in terms of spatial and contrast resolution,
compared to 2D Ideal.
Cube-IDEAL/Flex sequence could be very useful in measuring breast cancer size during follow-up evaluation of response to neo-adjuvant chemotherapy,
without contrast media administration.
1. Chen JH , Bahri S , Mehta RS , Kuzucan A , Yu HJ , Carpenter PM , Feig SA , Lin M , Hsiang DJ , Lane KT , Butler JA , Nalcioglu O , Su MY .Breast cancer: evaluation of response toneoadjuvantchemotherapywith 3.0-T MRimaging. Radiology. 2011 Dec;261(3):735-43.
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Xu JR.Can diffusion-weighted MR imaging and contrast-enhanced MR imaging precisely evaluate and predict pathological response to neoadjuvant chemotherapy in patients with breast...