To explore the potential of in-vivo MR spectroscopy in evaluation of breast masses.
Methods and Materials
In 30 patients with histopathologically proven primary breast cancer,
we performed breast MRI using dedicated breast coil using FSET1W,
STIR and Multiphase dynamic contrast enhanced sequence to look for additional lesions in the same as well as the contralateral breast.
In additional we performed MR spectroscopy of the known malignant breast mass. MRS Protocol: The breast spectroscopy sequence is a spin-echo sequence with regional saturation bands for outer volume suppression. •In our...
We evaluated; the lesion morphology and signal intensity on T1W,
T2W and STIR images and perfusion characteristics with parametric mapping and time intensity curves. We also evaluated the spectroscopy findings of the proven malignant breast masses and the additional lesions that were diagnosed as possibly malignant based on MRI characteristics. A total of 35 lesions were identified,
33 of them were malignant ( 2 patients had additional lesions,
confirmed on histopathology) and 2 were...
Discussion • The known limitation of MRS is that it provides the metabolic composition of a given voxel,
which may include more than one type of tissue,
for example in breast cancer; the voxel on occasions,
includes in addition to pathologic cancer tissue,
normal glandular tissue and adipose tissue. • The amplitude of choline peak is probably related to volume of pathologic tissue in a given voxel and hence the difference in the amplitude of choline peak,
depending on size of lesion. •The...
Evaluation of Breast Cancer Using Proton MR Spectroscopy: Total Choline Peak Integral and Signal-to-Noise Ratio as Prognostic IndicatorsAm.
2012198:W488-W497 Three-dimensional Proton MR Spectroscopic Imaging at 3 T for the Differentiation of Benign and Malignant Breast LesionsRadiologyDecember 1,
2011261:752-761 Determination of Choline Concentration in Breast Lesions: Quantitative Multivoxel Proton MR Spectroscopy as a Promising Noninvasive Assessment Tool to Exclude...