To evaluate the role of MRI: diffusion-weighted imaging (DWI) Dynamic contrast-study in assessing the response of uterine fibroids to high intensity focused ultrasound (HIFU) treatment.
Methods and Materials
From December 2008 to February 2010: 8 patients (mean age,
age range 46-52) with symptomatic uterine fibroids free of other pelvic pathology that required surgical intervention all patients underwent HIFU patients underwent MRI before and 6 months after treatment MAGNETIC RESONANCE IMAGING (MRI): multiplanar capacity and excellent soft tissue contrast resolution reflecting pathology Imaging protocol: 1.5-T MRI scanner and a multi-phased array coil (cardiac,
8 channels) T2-weighted...
Size before treatment: - Range : 5,2 cm to 15 cm - Mean : 7.8 cm Symptom presentation of 8 patients: - abdominal pain,
dysmenorrheal The mean ADC value of fibroids before treatment was: - 1,10 e -9 - range 0,42-1,40 e -9 The mean ADC value of fibroids after treatment increased andwas: - 1.73 e -9 - range1,60-2,00 e -9 Median reduction in tumor size as a percentage of initial tumor volume at 6 months after HIFU treatment was of 65% Mean fibroid enhancement before treatment was: -...
HIFU ablation appears to be an effective and safe treatment in reducing uterine fibroids volume. Both dynamic studyand DWI may serve as imaging tools to assess treatment response. In spite of the expected reduction of ADC values related to coagulative necrosis,
we observed an increase of ADC values.
This data should be confirmed in a larger study group and can be a matter of speculation in understanding the cellular effect of HIFU. Further studies are needed to understand the reliability of...
Quantitative Diffusion-Weighted Magnetic Resonance Imaging of Noral and Diseased Uterine Zones.
Acta Radiol 2009(3) .
The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis.
Eur J Radiol (2010),
BLOOD FLOW OCCLUSION VIA ULTRASOUND IMAGE-GUIDED HIGHINTENSITY FOCUSED ULTRASOUND AND ITS EFFECT ON TISSUE PERFUSION.
Ultrasound in Med.
Dr Virna Zampa,
Dr Valentina Vallini Diagnostic and Interventional Radiology Department of Oncology,
Transplants and Advanced Technologies in Medicine University of Pisa via Paradisa 2,
56100 Pisa email: firstname.lastname@example.org , email@example.com