To investigate the value of second look breast US with and without contrast enhanced MR volume navigation and fusion imaging (VNav) as reference.
Methods and Materials
Twenty-four patients (52±18 years, range 33-77) with additional lesions at conventional MR underwent bilateral contrast-enhanced (0.1 mmol/Kgbw Gd- BOPTA, Bracco Diagnostics) breast MR in supine position (1.5T, Achieva, Philips Healthcare) using T1-weighted high resolution isotropic examination volume and spectral attenuated inversion recovery fat suppression with body coil. Three fiducial, pills of vitamin E on the corresponding skin markers were used. US and MR coregistration was obtained...
Thirty-one additional lesions were detected in both MR exams. Pathologic examination showed 21 malignant and 10 benign lesions. Lesions diameter was 25±12 mm (mean±SD, range 7-43). 52% (11/21) of malignant and 60% (6/10) of benign lesions were detected only using VNav (p=0.0001). MR-guided biopsy was performed in three cases. Pathology demonstrated a 9 mm DCIS, a 8 mm sclerosing adenosis and a 12 mm atypical ductal hyperplasia.
Second look US with VNav showed a significant higher detection rate for additional MR-detected lesions increasing the possibility of tissue assessment using US- guided biopsy.
1. Sigurdson LJ, Kirkland SA. Breast volume determination in breast hypertrophy: an accurate method using two anthropomorphic measurements. Plast Reconstr Surg. 2006;118:313-320. 2. Kuhl CK, Schrading S, Leutner CC, et al. Mammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancer. J Clin Oncol. 2005;23:8469-8476. 3. Sardanelli F, Podo F, D'Agnolo G, et al. Multicenter comparative multimodality surveillance of women at...
Alfonso Fausto, M.D. Consultant Radiologist, Diagnostic Imaging Department San Giovanni di Dio General Hospital Viale Fatebenefratelli, 34 34170 Gorizia - Italy Email: email@example.com Ludovica Borghese, M.D. Consultant Radiologist, Diagnostic Imaging Department Casa di Cura Città di Udine Viale Venezia, 410 33100 Udine, Italy Email: firstname.lastname@example.org Giorgio Rizzatto, M.D. Director, Diagnostic Imaging Department San Giovanni di Dio General Hospital Viale Fatebenefratelli, 34 34170...