Aims and objectives
Alzheimer’s Disease (AD) is the most common cause of dementia worldwide.
So far univocal diagnosis of AD is only achieved by postmortem histology.
Beta-Amyloid plaques are known to be classical hallmarks of the post mortem Alzheimer´s Disease brain.
Beta-Amyloid deposits are currently detected by PiB-PET imaging,
which only provides a coarse localization of the affected areas.
On the other hand,
ultra-high field (UHF) MRI offers a potential non-invasive means to diagnose AD in...
Methods and materials
Two patients with autosomal dominant AD (female 51y,
male 35y) and two age and sex-matched healthy subjects (HS) were scanned at 9.4T using a multi-echo (N=5) 3D-GRE sequence (0.375x0.375x0.8mm 3 voxel size,
TR=35ms; TE=6 to 30ms in steps of 6ms,
matrix size=512x464x88) and a high resolution 3DGRE weighted sequence (AWI),
(0.130x0.130x0.6mm 3 voxel size,
TA=14min). A multi-echo (N=3) GRE sequence (100μm isotropic voxels,
A variation of 70m s-1 ca.
in the effective transverse relaxation rate was observed between grey and white matter in AD patient compared to healthy subject (Figure 1).
A pattern between grey and white matter,
corresponding to paramagnetic effects,
was also detected in the susceptibility map (0-0.04 ppm) of the AD patient with respect to the healthy subject (Figure 1).
the spatial resolution reached in-vivo was not sufficient to reveal microstructure of the cortical layers at higher...
Both R 2 * and QSM methods at ultra-high field hold promise for detecting Beta-Amyloid load within the cortical rim providing a potential means for early diagnosis of AD in-vivo. Optimization of the QSM algorithm would likely increase the power of Beta-Amyloid detection ex-vivo and in-vivo.
High Field Magnetic Resonance,
Max Planck Institute for Biological Cybernetics,
Germany. Phone: 00497071601944 Fax: + 31503617008 e-mail: firstname.lastname@example.org
de Ronde FM,
van Duinen SG,Webb AG,
van Buchem MA,
van der Weerd L.
MR microscopy of human amyloid-β deposits: characterization of arenchymal amyloid,
and vascular amyloid.
J Alzheimers Dis.
(2) van Rooden S.
The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease.