Aims and objectives
Percent mammographic density (MD),
measured as the proportion of fibrous and glandular tissue within the breast tissue area on a mammogram,
is a risk factor for breast cancer and is also associated with a number of known breast cancer risk factors including age,
body mass index (BMI),
and hormonal interventions including hormone replacement therapy (HRT) [1-5].
Women with extremely dense breasts have a four- to six-fold increased risk of breast cancer compared to...
Methods and materials
A frequency matched (1:2) case-control study design was employed to evaluate the relationship between visual assessment of MD on FFDM and breast cancer risk. All case and control subjects were women aged 40 to 75 at screen who had a digital screening examination performed through the Nova Scotia Breast Screening Program (NSBSP) between January 1,
2009 and June 30,
Case subjects were restricted to digital,
screen-detected unilateral invasive breast cancer cases (n = 429).
Of the 424 matched case-control sets identified,
63 individual observations were excluded because of missing data,
leaving a total of 392 cases and 817 controls for analysis. Characteristics of case and control subjects are summarized in Table 1.
Cases and controls were similar with respect to age at screen,
HRT use at time of screening,
and menopausal status. The binary regression tree analysis generated a tree model for which the predicted probability of breast...
To our knowledge this is the first study that provides a risk-based motivation for specific percentage mammographic density cut-points that are determined prior to,and independent of,
post-hoc validation of the relationship between the density scale and breast cancer risk. A significant strength of this study is the fact that cases are comprised of the entire province-wide population of all screen-detected unilateral breast cancer cases,
where all mammography imaging is done using FFDM.
Contact Author: Mohamed Abdolell,
Department of Diagnostic Radiology,
Clinical and epidemiological issues in mammographic density.
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Mammographic breast density as an intermediate phenotype for breast cancer.
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