Aims and objectives
This study aims to evaluate possible risk factors for future development of breast cancer which may be identified at the time of first (prevalent round) screen.
While there are multiple factors which are known toaffect breast cancer risk,
age at menarche,
hormone replacement therapy use,
and while risk modelling may be invoked to create an individual's risk profile (1-3),
it is not always feasibleto collect and interpret this information in the context of a large...
Methods and materials
Study Population This retrospective study adheres to local patient confidentiality requirements.
Our regional screening programmeassessment activity was reviewed over a one year period (April 2013-March 2014).
The study cohort included women in the standard screening age (50-70),
as well as those older than 70 who had the option of self-referral for screening.Prevalent round screen group was defined as women presenting for first screen without history of previous screening episodes.
39,491 women were screened over the study period (including self-referred women and excluding high risk or moderate risk women).
The age profile of the group assessed is shown in Figure 1 .
Of the study population,
7181 women had prevalent screens and 694 of these women were referred for assessment.
There were 370 biopsies and 73 cancers.
32311 women had incident screens and 1427 were referred for assessment.
There were 743 biopsies and 309 cancers. This information was obtained from the NBSS...
Multiple studies have shown that a history of a high risk lesion,
in particular a history of atypia,
confersincreased risk of developing breast cancer.
In their seminal work,
Dupont and Page found a 5.3 times greater risk of developing cancer in women with atypical hyperplasia compared to women with nonproliferative breast changes (5).
Hartmann and colleagues found that143/698 (20%) of women with a history of either ALH or ADH followed for a mean of 12.5 years developed cancer...
The authors would like to acknowledge VolparaSolutions and Philips for their support.
Implementation and outcomes of a multidisciplinary high-risk breast cancer program: the William Beaumont Hospital experience. Clin Breast Cancer .
2012;12:215-218. 2.Masood S.
Development of a Novel Approach for Breast Cancer Prediction and Early Detection Using Minimally Invasive Procedures and Molecular Analysis: How Cytomorphology Became a Breast Cancer Risk Predictor. Breast J .