To learn process of how the skull base generates and to know detailed and substantial morphologic changes on the skull base that is occurred in achondroplasia with embryology
Achondroplasia is the most common skeletal dysplasia.
It is caused by FGFR3 gene and MAPK signaling changes.
Hypoplasia of the skull base can cause neurological complications in achondroplasia.
Previous studies have shown that the small foramen magnum is implicated in sudden death and temporal bone rotation is partially related to hearing loss.
Although there have been many papers studying specific locations,
merely few reviews of imaging findings have been reported so far.
Findings and procedure details
Anatomy and development of the skull Terminology used to describe the embryology of the skull base is somewhat complicated,
and may need some explanation,
There are three different categories of classifications; 1) locations of the skull,
2) type of ossification and 3) mesenchymal origin.
One has to be aware that each term used to describe the same location does not necessarily match within the above mentioned three different categories. - We would like to first mention about the...
Understanding vital morphologic changes on the skull base with embryology helps you to know various neurological complications in achondroplasia.
Medical Embryology(11th) 2009.
The Developing Human(8th) 2007. 2.
CT of the temporal bone in achondroplasia.
AJNR Am J Neuroradiol.
Growth of the foramen magnum in achondroplasia.
Am J Med Genet.
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK...