Breast cancer is the most commonly diagnosed cancer among women in the western country,
accounting for a third of all female cancer cases,
and the second most common cause of cancer death.
(1) Mammmographic density is a strong risk factor for breast cancer,
but its potential application in risk management is not clear,
partly due to uncertainties about its interaction with other breast cancer risk factors.
We aimed to analyze the relationship between volumetric breast density (VBD) and risk...
Methods and materials
The study included 249 patients (fig 2) who underwent CR mammography in four views (RCC,
LMLO) between Jan 2014 and Jul 2014 self referring for screening.
For each patient the individual risk profile was determined using the Tyrer-Cuzick model,
counting for familial and personal factors.
A VBD value was computed from each mammogram (Volpara software),
and averaged among the four views to obtain the mean VBD per patient. Differences in lifetime risk distributions for four groups of...
The median lifetime risk was 11.0% for VG2,
14.5% for VG3,
and 15.6% for VG4.
Differences in lifetime risk between patients in VG2 and patients in VG3 and VG4 were significant (P-values equal to 0.0011 and 0.0002,
while risk was comparable for patients in VG3 and VG4 (P = 0.0931) (Fig6).
Lifetime risk increases with breast density.
Volumetric mammographic density measure might be used with existing risk prediction models to identify high-risk women more precisely .
Further studies with largest population and to compare women with BC vs thought without. Two study (23-24) have been performed to evaluate relationships between mammographic density and Tyrer Cuzick risk assessment model,
but both are limited from using a subjective optical or semiautomated methods which (as...
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