Breast tumor lesions often affect local diffusion of water molecules and microcirculation .
malignant tumors are often more vascularized than normal gland tissue or benign tumors .
the goal of this study was to assess whether Intravoxel Incoherent Motion (IVIM) parameters could be used to differentiate between benign and malignant lesions,
and also between histological sub-types and lesion grade.
Methods and Materials
Sample This study enrolled 34 women with a mean age±standard deviation of 57±12 years (age range of 30 to 83 years).
37 breast lesions were considered since some women had multiple lesions.
From these 37 lesions: 4 were benign lesions,
namely Fibroadenomas (FA),
and 33 were malignant lesions,
including 27 Invasive Ductal Carcinomas (IDC) and 6 Ductal Carcinoma In Situ (DCIS) ( Fig. 1 , Fig. 2 and Fig. 3 ).
Regarding the 27 IDC lesions: 5 IDC lesions were classified as on G1 grade,
Malignant breast lesions Benign lesions showed higher ADC,
D and D* mean values than malignant lesions.
On the other hand,
PF mean values were observed to be higher in malignant tissues than in benign tissues ( Table 1 and Fig. 4 ).
Significant differences were observed in ADC and D (p=0.007 and 0.005,
respectively) between benign and malignant lesions.
No other significant differences were observed. Histological lesion types – FA vs.
DCIS FA lesions showed higher ADC,
Le Bihan et al.
described for the first time the IVIM model and argued that it could distinguish molecular diffusion of water from the microcirculation of blood (perfusion) in brain tissue [2,4-6]. In this study ADC and D parameters were shown to be more robust in discriminating between lesion types and subtypes than D* and PF,
which reflect microcirculation. Benign lesions showed higher ADC and D mean values than malignant lesions.
This can be explained by the fact that malignant lesions...
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Intravoxel Incoherent Motion in Breast Lesions at 3 Tesla.
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Borlinhas Radiology Department,Instituto Português de Oncologia de Lisboa Francisco Gentil,
Portugal Institute of Biophysics and Biomedical Engineering,
Faculty of Sciences of the Universityof Lisbon,
Portugal E-Mail Address: email@example.com firstname.lastname@example.org F.
Borlinhas thanks the Instituto Português de Oncologia de Lisboa Francisco Gentil,
E.P.E.) and everyone that was involved in this project and made it possible. H.