|ESCR 2016 / P-0025|
|Increased epicardial fat and signs of impaired sistolic left ventricular function in NAFLD Patients: MRI evaluation and correlation with abdominal fat.|
The analysis of glucose metabolism and anthropometric parameters showed a relevant difference of body mass index (BMI) between NAFLD patients and control group (BMI NAFLD patients: 27 kg/m2 vs 22 kg/m2); a difference in insulin sensibility and resistance indexes was also found (HOMA index NAFLD patients: 2,82 ± 1,7 vs 1,43 ± 0,5; p= 0,034. OGIS index NAFLD patients: 11,04 ± 1,6 vs13,1 ± 1,1; p= 0,004). In patients’ group the volume of epicardial fat tissue measured with MRI was increased if compared with the control group (185±109 vs 52±30 cm3; p<0.0001), as well as its thickness measured with TTE (6.2±2.5 vs 2.8±3.5 mm; p=0.001). A direct positive correlation between epicardial and visceral adipose tissue was found in the subgroup of patients (n=13) who underwent the abdominal examination with MRI (r= 0.58; p = 0.03). Left ventricular ejection fraction was not statistically different between the groups, in both TTE and MRI evaluation ((52,3 ± 5,9 vs 55,2 ± 7,6; p= 0,36). In NAFLD patients’ group, TTE showed an increased end-systolic left ventricular diameter (30±4 vs 27±4 mm; p=0.015), even though MRI did not point out a significant difference in end-systolic volume between the two groups (75.4±29.8 vs 80.5±31.6 ml; p=0.81). TTE showed that E/A ratio, a diastolic dysfunction parameter, is reduced in NAFLD patients (1.2±0.3 vs 1.5±0.4; p=0.03). The 1st/2nd filling volume ratio measured with MRI using volume/time curves analysis was significantly reduced in NAFLD patients (1.6±1.5 vs 3.1±1.8; p=0.04).
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