Part of the session: EP-36 - Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology
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POSTER SECTIONS Coverpage Aim Materials & Methods Results Conclusion Disclosure 1 - Holding a Position (for details click on „i“) Disclosure 2 – Receiving Support (for details click on „i“) Disclosure 3 – Holding Property (for details click on „i“) Disclosure 4 – Having written Articles (for details click on „i“) References

EANM 20 / EP-266
Quercetin as a potential psychotherapeutic agent in a mouse model with acute exposure to cocaine: a preclinical PET study

Congress:	EANM 20
Poster No.:	EP-266
Type:	Scientific e-Poster
Keywords:	Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors:	F. M. Ribeiro¹, C. Nicolucci², M. Lapo Pais³, A. I. Santos⁴, P. M. Encarnação¹, A. L. Silva¹, I. F. Castro⁵, P. M. Correia¹, V. I. Assunção¹, J. F. Veloso¹, D. Priolli²; ¹Institute for Nanostructures, Nanomedelling and Nanofabrication (i3N), University of Aveiro, Aveiro, PORTUGAL, ²Multidisciplinary Research Laboratory, São Francisco University, Bragança Paulista, BRAZIL, ³Faculty of Sciences and Technology, University of Coimbra, Coimbra, PORTUGAL, ⁴Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, PORTUGAL, ⁵Radiation Imaging Technologies Lda (RI-TE), Ílhavo, PORTUGAL

Conclusion

Preclinical PET plays a fundamental role, not only in the validation of animal models for human brain disease, but also in the quantitative measurement of regional changes in brain activity. For the first time, it has been demonstrated that an acute single low dose of cocaine can induce metabolic neurological changes. In vivo ¹⁸F-FDG PET imaging proved to be a crucial tool to identify those brain changes, which must be considered regardless of the dosage used. Quercetin proved to be a neuropsychoprotective agent against this exposure.

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