EANM 20 / EP-266
Quercetin as a potential psychotherapeutic agent in a mouse model with acute exposure to cocaine: a preclinical PET study
Congress: EANM 20
Poster No.: EP-266
Type: Scientific e-Poster
Keywords: Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors: F. M. Ribeiro1, C. Nicolucci2, M. Lapo Pais3, A. I. Santos4, P. M. Encarnação1, A. L. Silva1, I. F. Castro5, P. M. Correia1, V. I. Assunção1, J. F. Veloso1, D. Priolli2; 1Institute for Nanostructures, Nanomedelling and Nanofabrication (i3N), University of Aveiro, Aveiro, PORTUGAL, 2Multidisciplinary Research Laboratory, São Francisco University, Bragança Paulista, BRAZIL, 3Faculty of Sciences and Technology, University of Coimbra, Coimbra, PORTUGAL, 4Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, PORTUGAL, 5Radiation Imaging Technologies Lda (RI-TE), Ílhavo, PORTUGAL

Conclusion

Preclinical PET plays a fundamental role, not only in the validation of animal models for human brain disease, but also in the quantitative measurement of regional changes in brain activity. For the first time, it has been demonstrated that an acute single low dose of cocaine can induce metabolic neurological changes. In vivo 18F-FDG PET imaging proved to be a crucial tool to identify those brain changes, which must be considered regardless of the dosage used. Quercetin proved to be a neuropsychoprotective agent against this exposure.

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