Part of the session: EP-36 - Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology
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POSTER SECTIONS Coverpage Aim Materials & Methods Results Conclusion Disclosure 1 - Holding a Position (for details click on „i“) Disclosure 2 – Receiving Support (for details click on „i“) Disclosure 3 – Holding Property (for details click on „i“) Disclosure 4 – Having written Articles (for details click on „i“) References

EANM 20 / EP-266
Quercetin as a potential psychotherapeutic agent in a mouse model with acute exposure to cocaine: a preclinical PET study

Congress:	EANM 20
Poster No.:	EP-266
Type:	Scientific e-Poster
Keywords:	Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors:	F. M. Ribeiro¹, C. Nicolucci², M. Lapo Pais³, A. I. Santos⁴, P. M. Encarnação¹, A. L. Silva¹, I. F. Castro⁵, P. M. Correia¹, V. I. Assunção¹, J. F. Veloso¹, D. Priolli²; ¹Institute for Nanostructures, Nanomedelling and Nanofabrication (i3N), University of Aveiro, Aveiro, PORTUGAL, ²Multidisciplinary Research Laboratory, São Francisco University, Bragança Paulista, BRAZIL, ³Faculty of Sciences and Technology, University of Coimbra, Coimbra, PORTUGAL, ⁴Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, PORTUGAL, ⁵Radiation Imaging Technologies Lda (RI-TE), Ílhavo, PORTUGAL

Results

Mice exposed to cocaine showed a metabolic activity decrease mainly at Striatum (SUV_St: 1.11±0.08) and Amygdala (SUV_AMY: 1.74±0.13) when compared to controls (saline group, SUV_St: 1.90±0.28 and SUV_AMY: 3.00±0.38). In opposition, tracer uptake increase for mice exposed to quercetin (SUV_St: 2.03±0.14 and SUV_AMY: 4.08±0.40). Once cocaine was administered followed to quercetin, its effects were mitigated by the latter (SUV_St: 2.03±0.07 and SUV_AMY: 3.46±0.33). Figures 1 and 2 illustrate ¹⁸F-FDG uptake for both St and AMY, respectively, according to the stimuli (saline, cocaine, quercetin or cocaine followed by quercetin).

« Materials & Methods Conclusion »

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