EANM 20 / EP-266
Quercetin as a potential psychotherapeutic agent in a mouse model with acute exposure to cocaine: a preclinical PET study
Congress: EANM 20
Poster No.: EP-266
Type: Scientific e-Poster
Keywords: Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors: F. M. Ribeiro1, C. Nicolucci2, M. Lapo Pais3, A. I. Santos4, P. M. Encarnação1, A. L. Silva1, I. F. Castro5, P. M. Correia1, V. I. Assunção1, J. F. Veloso1, D. Priolli2; 1Institute for Nanostructures, Nanomedelling and Nanofabrication (i3N), University of Aveiro, Aveiro, PORTUGAL, 2Multidisciplinary Research Laboratory, São Francisco University, Bragança Paulista, BRAZIL, 3Faculty of Sciences and Technology, University of Coimbra, Coimbra, PORTUGAL, 4Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, PORTUGAL, 5Radiation Imaging Technologies Lda (RI-TE), Ílhavo, PORTUGAL

Results

Mice exposed to cocaine showed a metabolic activity decrease mainly at Striatum (SUVSt: 1.11±0.08) and Amygdala (SUVAMY: 1.74±0.13) when compared to controls (saline group, SUVSt: 1.90±0.28 and SUVAMY: 3.00±0.38). In opposition, tracer uptake increase for mice exposed to quercetin (SUVSt: 2.03±0.14 and SUVAMY: 4.08±0.40). Once cocaine was administered followed to quercetin, its effects were mitigated by the latter (SUVSt: 2.03±0.07 and SUVAMY: 3.46±0.33). Figures 1 and 2 illustrate 18F-FDG uptake for both St and AMY, respectively, according to the stimuli (saline, cocaine, quercetin or cocaine followed by quercetin).

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