EANM 20 / EP-266
Quercetin as a potential psychotherapeutic agent in a mouse model with acute exposure to cocaine: a preclinical PET study
Congress: EANM 20
Poster No.: EP-266
Type: Scientific e-Poster
Keywords: Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors: F. M. Ribeiro1, C. Nicolucci2, M. Lapo Pais3, A. I. Santos4, P. M. Encarnação1, A. L. Silva1, I. F. Castro5, P. M. Correia1, V. I. Assunção1, J. F. Veloso1, D. Priolli2; 1Institute for Nanostructures, Nanomedelling and Nanofabrication (i3N), University of Aveiro, Aveiro, PORTUGAL, 2Multidisciplinary Research Laboratory, São Francisco University, Bragança Paulista, BRAZIL, 3Faculty of Sciences and Technology, University of Coimbra, Coimbra, PORTUGAL, 4Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, PORTUGAL, 5Radiation Imaging Technologies Lda (RI-TE), Ílhavo, PORTUGAL

Aim

The use of cocaine is increasing worldwide and currently represents one of the most frequent indications for drug treatment. Although cocaine chronic use has been shown to lead to neurotoxicity in rodents and humans, being associated with high morbidity and mortality rates, its recreational use, which may lead to addictive behaviour, is often neglected. In the absence of a specific treatment for addiction, there is an urgent need to develop therapeutic alternatives, having also a brain-protective effect from injuries caused by cocaine abuse. Flavonoids are pharmacological bases of drugs used to treat drug addiction, having antioxidant, neuroprotective, neurovascular, GABAergic and benzodiazepine properties. Quercetin, a flavonoid found in fruits and vegetables, has unique biological properties that can improve mental/physical performance and reduce infection risk, also acting as an important antioxidant, a blocker of neuronal toxicity and neurovascular changes [1-2]. PET dedicated to small animals plays a role in validating animal models of brain disease. The animals can be followed longitudinally over time, allowing investigation of the disease process, the development of compensatory changes, and long-term evaluation of the safety and efficacy of drug-based, surgical, cellular or gene-therapy based interventions [3-5]. This work aims to assess the functional activity of quercetin as a protective psychotropic drug, in animals exposed to a single and low dose of cocaine.

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