The use of cocaine is increasing worldwide and currently represents one of the most frequent indications for drug treatment. Although cocaine chronic use has been shown to lead to neurotoxicity in rodents and humans, being associated with high morbidity and mortality rates, its recreational use, which may lead to addictive behaviour, is often neglected. In the absence of a specific treatment for addiction, there is an urgent need to develop therapeutic alternatives, having also a brain-protective effect from injuries caused by cocaine abuse. Flavonoids are pharmacological bases of drugs used to treat drug addiction, having antioxidant, neuroprotective, neurovascular, GABAergic and benzodiazepine properties. Quercetin, a flavonoid found in fruits and vegetables, has unique biological properties that can improve mental/physical performance and reduce infection risk, also acting as an important antioxidant, a blocker of neuronal toxicity and neurovascular changes [1-2]. PET dedicated to small animals plays a role in validating animal models of brain disease. The animals can be followed longitudinally over time, allowing investigation of the disease process, the development of compensatory changes, and long-term evaluation of the safety and efficacy of drug-based, surgical, cellular or gene-therapy based interventions [3-5]. This work aims to assess the functional activity of quercetin as a protective psychotropic drug, in animals exposed to a single and low dose of cocaine.