Part of the session: EP-36 - Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology
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POSTER SECTIONS Coverpage Aim Materials & Methods Results Conclusion Disclosure 1 - Holding a Position (for details click on „i“) Disclosure 2 – Receiving Support (for details click on „i“) Disclosure 3 – Holding Property (for details click on „i“) Disclosure 4 – Having written Articles (for details click on „i“) References

EANM 20 / EP-268
Social stress-dependent changes on behavior and inflammatory parameters in animals with HPA-axis disruption

Congress:	EANM 20
Poster No.:	EP-268
Type:	Scientific e-Poster
Keywords:	Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors:	B. L. Giacobbo¹, R. Moraga-Amaro², L. Reali Nazario², A. Schildt², R. A. Dierckx², J. Doorduin², E. F. de Vries²; ¹Umeå University, Umeå, SWEDEN, ²University Medical Center Groningen, Groningen, NETHERLANDS

Fig. 1: No effect of surgery or RSD on the percentage of time spent in the center of...

Fig. 2: Effect of ADX and RSD on the time spent interacting with stimulus animal. Boxes...

Fig. 3: No significant effect of ADX or social defeat on the uptake of [11C]PBR28 in...

Fig. 4: Iba-1 Immunohistochemistry. A) Regions of interest were delineated following...

Aim

Chronic stress is associated with a deregulation of the hypothalamus-pituitary adrenal (HPA) axis and can result in behavioral abnormalities, such as depressive behavior. Adrenalectomy (ADX) inhibits the production and release of corticosterone, impairing the response towards stressors, and thus may prevent stress-induced depressive behavior. We aim to determine behavioral and neuroinflammatory effects of HPA-axis disruption via bilateral adrenalectomy (ADX) in animals submitted to repeated...

Materials & Methods

8-weeks old male Wistar rats were divided into four groups: ADX+RSD; ADX+Control; Sham+RSD; Sham+Control. Seven days after ADX surgery, animals were submitted to a 5 days RSD or Control protocols. One- and two days after the last RSD trial, animals went through an open field and social interaction test, respectively. 14 days after RSD, animals went through a 30 minutes [ 11 C]-PBR28 scan for microglia activation. Multifactorial ANOVA was performed for statistical assessment.

Results

There was a significant effect of RSD (p=0.038) and ADX (p=0.049) on the social interaction of the animals, as well as an interaction between surgery and RSD (p=0.042). Post-hoc analysis showed a significantly lower social interaction of Sham+RSD when compared with the other groups (vs. Control+ADX, p=0.032; Control+Sham, p=0.023; ADX+RSD, p=0.035). Open field analysis showed no anxiety-like behavior nor locomotion effect of RSD or ADX (p>0.05). Microglial activation assessed through [ 11...

Conclusion

HPA-axis signaling disruption is able to counterbalance the impairment on the social behavior of these animals. In contrast, no effects of ADX or RSD were observed in other behavioral paradigms. Neuroinflammation was also not observed two weeks after the RSD, suggesting that the inflammatory response of microglial cells is too mild to be detected by PET or that neuroinflammation was only transient and already resolved at the time of measurement.

Disclosure 1 - Holding a Position (for details click on „i“)

Nothing to disclose

Disclosure 2 – Receiving Support (for details click on „i“)

Nothing to disclose

Disclosure 3 – Holding Property (for details click on „i“)

Nothing to disclose

Disclosure 4 – Having written Articles (for details click on „i“)

Nothing to disclose

References

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