Part of the session: EP-36 - Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology
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POSTER SECTIONS Coverpage Aim Materials & Methods Results Conclusion Disclosure 1 - Holding a Position (for details click on „i“) Disclosure 2 – Receiving Support (for details click on „i“) Disclosure 3 – Holding Property (for details click on „i“) Disclosure 4 – Having written Articles (for details click on „i“) References

EANM 20 / EP-265
Metabolic changes in an animal model of Amyotrophic Lateral Sclerosis by [¹⁸F]-Fluorodeoxyglucose

Congress:	EANM 20
Poster No.:	EP-265
Type:	Scientific e-Poster
Keywords:	Preclinical Studies -> Preclinical Studies -> Preclinical Cardiology and Neurology, 4. Cardiovascular System, 401 Basic Science, 5. Neurosciences, 501 Basic Science,
Authors:	B. L. Giacobbo, T. Mediavilla, J. Axelsson, M. Ericsson, D. Marcellino, F. Sultan; Umeå University, Umeå, SWEDEN

Aim

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that affects motor neurons, leading to muscle atrophy, paralysis, and eventual respiratory failure. As with many other neurodegenerative disorders, neuronal apoptosis is often associated with a loss of neuronal function and metabolic changes. [ 18 F]-FDG is a well-validated biomarker to observe metabolic changes in several brain disorders in humans, but its use in preclinical ALS research is not yet widespread. We aim...

Materials & Methods

Animals (6 SOD1 WT , 7 SOD1 G93A ) were previously genotyped for mutant SOD1 using qPCR. When SOD1 G93A animals started to develop ALS-like symptoms, animals were fasted for 4 hours and then injected intravenously with [ 18 F]-FDG (injected dose of 10.8±2 MBq). One hour after injection, animals were placed in a microPET-CT scanner (Mediso nanoPET-CT) and scanned (5 minutes for CT, 10 minutes for PET). CT data was used for attenuation correction. After reconstruction, data were coregistered to...

Results

Our SUVR data suggest a significant metabolic deregulation in SOD1 G93A animals when analyzing [ 18 F]-FDG in the brain. There was significant hypometabolism in anterior cingulate cortex (9% decrease in SOD1 G93A vs. SOD1 WT for both left and right hemispheres), in left entorhinal cortex (14% decrease), left hippocampus (12% decrease), right nose-associated primary somatosensory cortex (6% decrease), left supplementary somatosensory cortex (8% decrease), thalamus (11% and 8% for left and...

Conclusion

These preliminary findings suggest a significant metabolic deregulation in animals with mutant SOD1 that develop ALS disease. Since animals were scanned after developing ALS symptoms, further studies aimed to study brain metabolism with [ 18 F]-FDG in prodromal stages of disease are warranted. This would provide us better insight into the usefulness of metabolic radiotracers for the detection of disease onset and progression, as well as the efficacy of therapeutic treatment strategies.

Disclosure 1 - Holding a Position (for details click on „i“)

Nothing to disclose

Disclosure 2 – Receiving Support (for details click on „i“)

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Disclosure 3 – Holding Property (for details click on „i“)

Nothing to disclose

Disclosure 4 – Having written Articles (for details click on „i“)

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References

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