Aims and objectives
Chronic obstructive pulmonary disease (COPD) was listed as the third leading cause of death by the World Heath Organization with 3.1 million deaths per year.
COPD mainly charaterized by irreversible airway obstructions,
is largely avoidable and caused by inhaled noxae respectivley particles.
Besides clinical criteria,
the diagnostic guidelines for COPD are based on spirometric measurements of forced expiratory volume in one second (FEV1) and forced vital capacity...
Methods and materials
Lung function testing
Forty-six patients with diagnosed COPD underwent body plethysmography,
acquiring the following parameters: vital capacity (VC),
forced expiratory volume (FEV1),
Tiffeneau index (FEV1%VC),
residual volume (RV),
total lung capacity (TLC),
ratio of residual volume to TLC (RV%TLC) and specific total airway resistance (sRtot).
Except for FEV1%VC and RV%TLC,
all values are given as percent of predicted,
as calculated accoring to ATS/ERS recommendations.
expiratory and delta values,
we were able to show statistically significant correlations between every qCT parameter and each body plethysmography parameter in either of one of the analysis (inspiration,
there was a strong difference in correlation distribution between inspiratory and the expiratory qCT scan as well as the delta values,
as seen exemplified for the MLD in Table 1.
As shown in the correlation heatmaps (Fig.
3 & 4),...
Expiratory qCT and calculated delta values between inspiratory and expiratory scans significantly improve the correlation with lung function parameters.
an additional expiratory qCT may improve image based phenotyping of patients with COPD.
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