· To understand the pathophysiology,
clinical manifestations and disease spectrum of Crohn’s disease;
· To illustrate the important radiological features of Crohn’s disease that can allow a correct differential diagnosis in the setting of acute bowel disease.
Crohn’s disease is a systemic disease that can involve any portion of the gastrointestinal tract,
although the small bowel is the most commonly affected portion of the bowel,
particularly the distal ileum (80%).
a significant proportion also has colonic involvement and up 20% of patients have large bowel involvement only.
Crohn's lesions have a segmental and asynchronous distribution.[5,7]
Approximately 20% with small or large bowel involvement also have perianal disease,
Findings and procedure details
Crohn disease remains a difficult entity to diagnose clinically.
While involvement of any segment of the gastrointestinal tract is possible,
the disease most often affects the distal ileum,
making direct endoscopic evaluation and biopsy difficult.
symptoms tend to be nonspecic,
and there are no clinical symptoms or laboratory markers that allow a specific diagnosis.
While involvement of the small bowel is more common,
Crohn’s disease can also involve the large bowel,
and in some...
The multidetector computed tomography has become crucial for the diagnosis of Crohn’s disease and its complications,
with a proven efficacy in identifying the enteric and extraenteric manifestations of the disease.
This modality can clearly depict inflammatory lesion activity and conditions that require elective gastrointestinal surgery,
thereby aiding in treatment planning.
Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago? World J Gastroenterol (2014) September 7; 20(33): 11486-11495
2. Walree I.C.
et al. Late-onset inflammatory bowel disease in
the very elderly. The Netherlands Journal of Medicine (2015). January 2015,
(2015) MDCT of acute colitis in adults: An update in current imaging features.