Review the physics principles of DW imaging. Describe the DW imaging technique: sequences,
selection of b values,
aparent diffusion coefficient (ADC) maps. Describe the apperance of normal body structures on DWI. Summarize the clinical applications of DW imaging in paediatric imaging (brain,
head&neck and body),
including tensor diffusion imaging (DTI) in central nervous system (CNS) assesment and whole body MRI.
DW imaging is widely used in neuroimaging but in the latest years it is also increasly used in body imaging.
It has an important role in a wide variety of pathologies including detection of abscesses,
evaluation of inflammatory bowel disease,
grading of liver fibrosis and cirrosis,
but is especially used in oncologic imaging for tumour detection and characterization,
assessment of therapy response and monitoring of tumours.
Findings and procedure details
1. Physics principles of DW imaging. When we talk about diffusion imaging we have in our mind the concept of Brownian motion of water molecules; according to theoretic models,
the trajectory of a single molecule can be envisioned as a series of random collisions with surrounding molecules,
all of which are agitated by thermal energy. The tissues characteristics define the type of movement of water molecules,
according to this, Diffusion imaging can be divided in two types : Isotropic : occurs...
DW imaging as a biomarker is very helpful in oncologic imaging,
because it allow us to have information about the microenviroment of tissues and lesions.
it plays and important role for the tumour detection and characterization process and even more,
to the follow up.
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